Review What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel
نویسندگان
چکیده
L. TESTA, R. BHINDI, W.J. VAN GAAL, R.A. LATINI, S. PIZZOCRI, S. LANOTTE, G.G.L. BIONDI ZOCCAI, M. VALGIMIGLI, M.L. LAUDISA, N. BRAMBILLA, A.P. BANNING and F. BEDOGNI From the Interventional Cardiology Department, S. Ambrogio Clinical Institute, Milan, Italy, Department of Cardiology, Royal North Shore Hospital and North Shore Heart Research Centre, Kolling Institute, University of Sydney, Institute of Cardiology, Northern Hospital, Melbourne, Australia, Institute of Cardiology, Ospedale ‘Le Molinette’, University of Turin, Turin, Department of Cardiology, Arcispedale S Anna, University of Ferrara, Ferrara, Italy and John Radcliffe Hospital, Oxford, UK
منابع مشابه
What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel.
Thienopyridines are a class of drug targeting the platelet adenosine diphosphate 2 receptor. They have been shown to significantly reduce platelet activity exerting an important role in those clinical settings in which such an effect is beneficial. Ticlopidine was first to be introduced several years ago but it was quickly replaced by clopidogrel as it had a better risk/benefit profile. Recentl...
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This study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, Peshawar from 15th October 2007 to 20th December 2007. We included 105 su...
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Prasugrel, trade name Effient, is an investigational new antiplatelet drug currently under review for clinical use by the Food and Drug Administration. It is a thienopyridine analog with a structure similar to that of clopidogrel and ticlopidine. Thienopyridine derivatives inhibit platelet aggregation induced by adenosine diphosphate by irreversibly inhibiting the binding of adenosine diphospha...
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